CJC-1295 (DAC + IPA Blend)
For Research Use Only. Not for human or veterinary use.
Product Overview
CJC-1295 (No DAC) — also known as Modified GRF 1-29 — is a synthetic analog of growth hormone-releasing hormone (GHRH) comprising the first 29 amino acids of the native GHRH sequence with four amino acid substitutions to improve stability. Unlike the DAC (drug-affinity complex) variant, this form lacks the lysine-maleimide modification, resulting in a shorter half-life that preserves the pulsatile character of growth hormone (GH) release in research models. It is used in studies examining pituitary GHRH receptor pharmacology and GH axis signaling.
Specifications
| Parameter | Specification |
|---|---|
| Product Name | CJC-1295 (No DAC) / Modified GRF 1-29 |
| CAS Number | 863288-34-0 |
| Molecular Formula | C₁₅₂H₂₅₂N₄₄O₄₂ |
| Molecular Weight | ~3367 Da |
| Purity | ≥99% (HPLC) |
| Appearance | White lyophilized powder |
| Storage | -20°C, protect from light |
Available Packaging
Supplied as 10 mg × 10 vials per box.
Research Background
CJC-1295 (No DAC) represents the GHRH(1-29) fragment class of research peptides, engineered with amino acid substitutions at positions 2, 8, 15, and 27 to resist enzymatic degradation while retaining GHRH receptor binding affinity. The absence of the DAC moiety means plasma half-life remains in the range of 30–60 minutes in animal models, which is important for research designed to study physiologically pulsatile GH secretion patterns.
Research applications have primarily focused on pituitary GHRH receptor pharmacology, including receptor binding kinetics, second-messenger cAMP signaling cascades, and somatotroph cell activation in rodent pituitary tissue preparations. Comparative studies between the No DAC and DAC variants provide insights into how half-life modification affects GH pulse amplitude and frequency in animal model systems.
Additional research has examined downstream effects of GHRH receptor stimulation on IGF-1 axis signaling in rodent models, contributing to understanding of the somatotropic axis and its regulatory mechanisms under controlled laboratory conditions.
Quality Control
- HPLC purity verification (≥99%)
- Mass spectrometry identity confirmation
- Endotoxin tested
- Certificate of Analysis (COA) provided per lot
- Batch traceability maintained
Handling & Storage
Store unopened lyophilized powder at -20°C. After reconstitution with bacteriostatic or sterile water, store at 2–8°C and use within recommended stability window. Avoid repeated freeze-thaw cycles. Material should only be handled by trained laboratory personnel using appropriate PPE.
Bulk & Custom Orders
Glunova Biotech LLC supplies research institutions, universities, and contract research organizations worldwide. For bulk pricing, custom packaging, or supply agreements, contact dylan.tom2012@gmail.com.
Safety Data Sheet (SDS)
SDS for this product is currently in preparation. For interim safety documentation, hazard classification, or handling guidance, contact dylan.tom2012@gmail.com. We provide preliminary safety data within 1 business day to verified research institutions.
This product is sold strictly for laboratory research purposes. It is not a drug, food, cosmetic, or dietary supplement. It is not approved by the FDA for human or veterinary use. Resale or transfer for non-research applications is prohibited.