GHRP-6

For Research Use Only. Not for human or veterinary use.

Product Overview

GHRP-6 (Growth Hormone Releasing Peptide-6) is a synthetic hexapeptide with the sequence His-D-Trp-Ala-Trp-D-Phe-Lys-NH₂ that acts as an agonist at the ghrelin receptor (GHS-R1a). It belongs to the growth hormone secretagogue peptide class and is one of the most extensively studied GHS-R1a agonists, widely used as a research tool for investigating the ghrelin receptor system and GH secretory physiology. This research-grade lyophilized material is supplied exclusively for in-vitro and laboratory investigation.

Specifications

Parameter	Specification
Product Name	GHRP-6
CAS Number	87616-84-0
Molecular Formula	C₄₆H₅₆N₁₂O₆
Molecular Weight	873.01 g/mol
Purity	≥99% (HPLC)
Appearance	White lyophilized powder
Packaging	10mg × 10 vials
Storage	-20°C, protect from light

Chemical Structure

Research Background

GHRP-6 was among the first synthetic peptides identified as potent GH secretagogues, and its discovery contributed significantly to the eventual identification of the endogenous ghrelin receptor system. Published research has characterized GHRP-6 as a GHS-R1a agonist that stimulates GH release through a mechanism distinct from GHRH, involving activation of phospholipase C and intracellular calcium mobilization in somatotroph cell models. It is commonly used as a reference compound in GHS-R1a pharmacology research.

A notable feature documented in animal model research is GHRP-6’s appetite-stimulating effect, which has been studied in the context of ghrelin receptor biology and hypothalamic neuropeptide Y (NPY) signaling. Rodent studies have examined orexigenic responses and food intake behavior following GHS-R1a activation, making GHRP-6 a useful research tool for investigating the intersection of the GH axis and energy homeostasis pathways.

Research has also investigated GHRP-6 in cellular protection studies, particularly in cardiac and hepatic cell models. Published studies have explored cytoprotective signaling downstream of GHS-R1a activation, examining pathways including PI3K/Akt and ERK1/2 in experimental ischemia models. GHRP-6 is widely employed as a comparator peptide in structure-activity relationship studies examining selectivity profiles among GHS-R1a agonists including Ipamorelin, GHRP-2, and Hexarelin.

Quality Control

• HPLC purity verification (≥99%)
• Mass spectrometry identity confirmation
• Endotoxin tested
• Certificate of Analysis (COA) provided per lot
• Batch traceability maintained

Handling & Storage

Store unopened lyophilized powder at -20°C. After reconstitution with bacteriostatic or sterile water, store at 2–8°C and use within recommended stability window. Avoid repeated freeze-thaw cycles. Material should only be handled by trained laboratory personnel using appropriate PPE and within validated research workflows.

Bulk & Custom Orders

Glunova Biotech LLC supplies research institutions, universities, and contract research organizations worldwide. For bulk pricing, custom packaging, or supply agreements, contact dylan.tom2012@gmail.com.

Safety Data Sheet (SDS)

SDS for this product is currently in preparation. For interim safety documentation, hazard classification, or handling guidance, contact dylan.tom2012@gmail.com. We provide preliminary safety data within 1 business day to verified research institutions.

This product is sold strictly for laboratory research purposes. It is not a drug, food, cosmetic, or dietary supplement. It is not approved by the FDA for human or veterinary use. Resale or transfer for non-research applications is prohibited.