MOTS-C

For Research Use Only. Not for human or veterinary use.

Product Overview

MOTS-C is a 16-amino-acid mitochondrial-derived peptide (MDP) encoded within the 12S rRNA gene of the mitochondrial genome (mtDNA). It belongs to the emerging class of mitochondrial open reading frame peptides (MOFs) and has been investigated as a research tool in metabolic biology, AMPK signaling, and mitochondrial-nuclear communication studies. This research-grade lyophilized material is supplied exclusively for in-vitro and laboratory investigation.

Specifications

Parameter	Specification
Product Name	MOTS-C
CAS Number	1627580-64-6
Molecular Formula	C₇₅H₁₃₂N₂₈O₂₂S
Molecular Weight	2174.1 g/mol
Purity	≥99% (HPLC)
Appearance	White lyophilized powder
Packaging	20mg × 10 vials
Storage	-20°C, protect from light

Chemical Structure

Research Background

MOTS-C was identified as a mitochondrially encoded peptide translated from a conserved open reading frame within the 12S ribosomal RNA gene. Published studies have investigated its capacity to translocate from mitochondria to the nucleus in response to metabolic stress, where it has been reported to modulate gene expression related to oxidative stress response and metabolic homeostasis. This mitochondrial-to-nuclear communication axis has been a focal point of research into inter-organelle signaling.

Research has examined MOTS-C as an activator of AMPK (AMP-activated protein kinase) signaling in cell culture and rodent models. Studies have explored its role in glucose uptake regulation, GLUT4 translocation in skeletal muscle cell models, and folate-methionine cycle modulation. These investigations position MOTS-C as a research probe for studying metabolic pathway regulation and mitochondrial peptide biology.

Additional published research has investigated MOTS-C in the context of aging biology and exercise-associated metabolic signaling. Studies in rodent models have examined circulating MOTS-C levels in relation to metabolic markers, contributing to research on mitochondrial-derived peptides as endocrine-like signaling molecules. The peptide is also studied in the context of insulin sensitivity pathways using in-vitro adipocyte and myocyte model systems.

Quality Control

• HPLC purity verification (≥99%)
• Mass spectrometry identity confirmation
• Endotoxin tested
• Certificate of Analysis (COA) provided per lot
• Batch traceability maintained

Handling & Storage

Store unopened lyophilized powder at -20°C. After reconstitution with bacteriostatic or sterile water, store at 2–8°C and use within recommended stability window. Avoid repeated freeze-thaw cycles. Material should only be handled by trained laboratory personnel using appropriate PPE and within validated research workflows.

Bulk & Custom Orders

Glunova Biotech LLC supplies research institutions, universities, and contract research organizations worldwide. For bulk pricing, custom packaging, or supply agreements, contact dylan.tom2012@gmail.com.

Safety Data Sheet (SDS)

SDS for this product is currently in preparation. For interim safety documentation, hazard classification, or handling guidance, contact dylan.tom2012@gmail.com. We provide preliminary safety data within 1 business day to verified research institutions.

This product is sold strictly for laboratory research purposes. It is not a drug, food, cosmetic, or dietary supplement. It is not approved by the FDA for human or veterinary use. Resale or transfer for non-research applications is prohibited.