NAD+

For Research Use Only. Not for human or veterinary use.

Product Overview

NAD+ (Nicotinamide Adenine Dinucleotide) is a ubiquitous coenzyme found in all living cells, serving as a central cofactor in cellular redox reactions and as a substrate for key regulatory enzymes including sirtuins (SIRTs) and poly(ADP-ribose) polymerases (PARPs). It belongs to the pyridine nucleotide coenzyme class and is a fundamental research tool in metabolism, aging biology, and DNA repair pathway studies. This research-grade lyophilized material is supplied exclusively for in-vitro and laboratory investigation.

Specifications

Parameter	Specification
Product Name	NAD+ (Nicotinamide Adenine Dinucleotide)
CAS Number	53-84-9
Molecular Formula	C₂₁H₂₇N₇O₁₄P₂
Molecular Weight	663.43 g/mol
Purity	≥99% (HPLC)
Appearance	White lyophilized powder
Packaging	1000mg × 10 vials
Storage	-20°C, protect from light

Chemical Structure

Research Background

NAD+ occupies a central position in cellular metabolism as an electron carrier in oxidative phosphorylation and glycolysis, cycling between its oxidized (NAD+) and reduced (NADH) forms. Beyond its redox function, research has extensively characterized NAD+ as a substrate consumed by sirtuin deacylases (SIRT1–SIRT7) and PARP enzymes (PARP1, PARP2) — families of proteins studied for their roles in gene silencing, DNA damage response, and metabolic regulation. Published studies have documented that intracellular NAD+ availability directly influences the catalytic activity of these enzyme classes in cell culture systems.

A substantial body of research has examined the relationship between NAD+ levels and aging-associated cellular changes. Studies in yeast, worm, and rodent models have investigated how declining NAD+ availability with age correlates with changes in mitochondrial function, sirtuin activity, and DNA repair capacity. These investigations have utilized exogenous NAD+ supplementation in in-vitro and ex-vivo systems to explore whether restoring NAD+ pools influences cellular markers associated with metabolic and aging research endpoints.

Research has also employed NAD+ in PARP pathway studies, particularly in the context of genotoxic stress and DNA strand-break repair. Cell-based models using NAD+ depletion and repletion approaches have been used to investigate PARP-1 activation dynamics, PAR chain synthesis, and energy crisis mechanisms in stressed cellular systems. The lyophilized form supplied by Glunova Biotech is designed for in-vitro reconstitution studies requiring precise, research-grade NAD+ preparations with verified purity for enzymatic and cell-based assays.

Quality Control

• HPLC purity verification (≥99%)
• Mass spectrometry identity confirmation
• Endotoxin tested
• Certificate of Analysis (COA) provided per lot
• Batch traceability maintained

Handling & Storage

Store unopened lyophilized powder at -20°C. After reconstitution with bacteriostatic or sterile water, store at 2–8°C and use within recommended stability window. Avoid repeated freeze-thaw cycles. Material should only be handled by trained laboratory personnel using appropriate PPE and within validated research workflows.

Bulk & Custom Orders

Glunova Biotech LLC supplies research institutions, universities, and contract research organizations worldwide. For bulk pricing, custom packaging, or supply agreements, contact dylan.tom2012@gmail.com.

Safety Data Sheet (SDS)

SDS for this product is currently in preparation. For interim safety documentation, hazard classification, or handling guidance, contact dylan.tom2012@gmail.com. We provide preliminary safety data within 1 business day to verified research institutions.

This product is sold strictly for laboratory research purposes. It is not a drug, food, cosmetic, or dietary supplement. It is not approved by the FDA for human or veterinary use. Resale or transfer for non-research applications is prohibited.