Selank

For Research Use Only. Not for human or veterinary use.

Product Overview

Selank is a synthetic heptapeptide with the sequence Thr-Lys-Pro-Arg-Pro-Gly-Pro, derived from the endogenous immunomodulatory tetrapeptide tuftsin (Thr-Lys-Pro-Arg) with a C-terminal Pro-Gly-Pro extension to enhance metabolic stability. It belongs to the tuftsin-derived neuropeptide class and has been investigated in neurochemistry and anxiolytic research, primarily in rodent behavioral and cell-based models. This research-grade lyophilized material is supplied exclusively for in-vitro and laboratory investigation.

Specifications

Parameter	Specification
Product Name	Selank
CAS Number	129954-34-3
Molecular Formula	C₃₃H₅₇N₁₁O₉
Molecular Weight	751.87 g/mol
Purity	≥99% (HPLC)
Appearance	White lyophilized powder
Packaging	10mg × 10 vials
Storage	-20°C, protect from light

Chemical Structure

Research Background

Selank was developed at the Institute of Molecular Genetics of the Russian Academy of Sciences as a tuftsin analog with enhanced stability against peptidase degradation. Published research from Russian academic institutions has investigated Selank in rodent anxiety models, examining behavioral endpoints in elevated plus maze and open-field paradigms. Studies have explored its interaction with GABAergic and serotonergic systems, with some research documenting modulation of GABA-A receptor sensitivity in cell-based models.

A distinct area of Selank research has focused on brain-derived neurotrophic factor (BDNF) and its associated signaling pathways. Studies in rodent models have examined changes in BDNF mRNA expression and TrkB receptor activation following peptide administration under controlled experimental conditions. This work contributes to research on neuropeptide modulation of neurotrophic factor systems, a topic of broad interest in neuroscience research.

Research has also investigated Selank’s immunomodulatory properties, given its structural derivation from tuftsin, which is known to interact with phagocytic cell receptors. Studies have examined interleukin expression profiles and T-cell responses in immune cell culture models, investigating whether the Pro-Gly-Pro extension influences the immunological activity of the parent tuftsin sequence. The peptide serves as a research probe for studying neuropeptide-immune system interactions in laboratory settings.

Quality Control

• HPLC purity verification (≥99%)
• Mass spectrometry identity confirmation
• Endotoxin tested
• Certificate of Analysis (COA) provided per lot
• Batch traceability maintained

Handling & Storage

Store unopened lyophilized powder at -20°C. After reconstitution with bacteriostatic or sterile water, store at 2–8°C and use within recommended stability window. Avoid repeated freeze-thaw cycles. Material should only be handled by trained laboratory personnel using appropriate PPE and within validated research workflows.

Bulk & Custom Orders

Glunova Biotech LLC supplies research institutions, universities, and contract research organizations worldwide. For bulk pricing, custom packaging, or supply agreements, contact dylan.tom2012@gmail.com.

Safety Data Sheet (SDS)

SDS for this product is currently in preparation. For interim safety documentation, hazard classification, or handling guidance, contact dylan.tom2012@gmail.com. We provide preliminary safety data within 1 business day to verified research institutions.

This product is sold strictly for laboratory research purposes. It is not a drug, food, cosmetic, or dietary supplement. It is not approved by the FDA for human or veterinary use. Resale or transfer for non-research applications is prohibited.